Neoprobe sentinel node biopsy1/17/2024 (10)70207-2Ĭardoso F, Cataliotti L, Costa A, Knox S, Marotti L, Rutgers E, Beishon M (2017) European Breast Cancer Conference manifesto on breast centres/units. Krag DN, Anderson SJ, Julian TB, Brown AM, Harlow SP, Costantino JP, Ashikaga T, Weaver DL, Mamounas EP, Jalovec LM, Frazier TG, Noyes RD, Robidoux A, Scarth HMC, Wolmark N (2010) Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lyman GH, Temin S, Edge SB, Newman LA, Turner RR, Weaver DL, Benson AB 3rd, Bosserman LD, Burstein HJ, Cody H 3rd, Hayman J, Perkins CL, Podoloff DA, Giuliano AE, American Society of Clinical Oncology Clinical Practice (2014) Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update. Lanng C, Hoffmann J, Galatius H, Engel U (2007) Assessment of clinical palpation of the axilla as a criterion for performing the sentinel node procedure in breast cancer. J Med Liban 57(2):65–71īhargavan RV, Mirza A, Cherian K, Krishna J, Augustine P (2020) Level III dissection in locally advanced breast cancer following neoadjuvant chemotherapy: a retrospective study. Ghossain A, Ghossain MA (2009) History of mastectomy before and after Halsted. Age, body mass index, laterality, quadrant, grade, biology, and pathological T size had no impact on the identification rate. Sentinel lymph node using dual tracer has a high identification rate and a low false negative rate post lumpectomy. Demographic factors such as age, body mass index, laterality, quadrant, biology, grade, and pathological T stage had no impact on the identification rate. Sensitivity ( n = 9/9) and specificity ( n = 19/19) of frozen section were 100% with a false negative rate of 0% (0/19). Maximum yield was seen for hot and blue nodes (1.86). Average sentinel nodal yield/patient was 3.6 (range 0–7). Sentinel node identification rate was 86.7% ( n = 26/30) for scintigraphy alone and 96.7% ( n = 29/30) using combined method. The primary end point was sentinel node identification rate and accuracy of nodal frozen section. Completion axillary nodal dissection was performed in all cases. Sentinel nodes were identified based on blue dye uptake and gamma probe and sent for intra operative frozen section. SLNB was performed by preoperative lymphoscintigram using technetium-labeled human serum albumin followed by intraoperative blue dye injection. This prospective interventional study was conducted over 1 year on 30 post lumpectomy pT1/2 cN0 patients. There is limited data on the role and efficacy of the same in the post lumpectomy scenario. Sentinel lymph node biopsy (SLNB) is the gold standard for the evaluation of axilla in clinically node-negative early breast cancers.
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